Instant Ocean Bio-Spira for Saltwater Aquariums prevents new tank syndrome and makes marine aquariums fish-safe instantly. It accelerates the establishment of the bio-filter in a newly setup saltwater aquarium. The live bacteria start working immediately to provide a safe and healthy environment for your fish without the long wait. Bio-Spira can also be used after a water change, when adding new fish, or after medicating. Their patented mix of nitrococcus, nitrosomonas, nitrosospira, and nitrospira is proven to work.